李百祺特聘教授的個人資料 - Profile of Pai-Chi Li

李百祺 Pai-Chi Li

國立台灣大學電機工程學系 特聘教授
國立臺灣大學生醫電子與資訊學研究所 特聘教授
國立臺灣大學電機工程學系 特聘教授
國立臺灣大學醫療器材與醫學影像研究所 特聘教授
國立臺灣大學重點科技研究學院 特聘教授
國家衛生研究院醫工組 兼任研究員
Distinguished Professor, Department of Electrical Engineering, National Taiwan University
Distinguished Professor, Institute of Biomedical Electronics and Bioinformatics, National Taiwan University
Distinguished Professor, Institute of Medical Device and Imaging, National Taiwan University
Distinguished Professor, Graduate School of Advanced Technology, National Taiwan University
Adjunct PI, National Health Research Institutes

主要研究領域:

生物醫學工程、生醫光聲技術、超音波影像與治療、醫材創新

Major Research Areas:

Biomedical Engineering, Biomedical Photoacoustics, Ultrasound Imaging and Therapy, Medical Device Innovation

研究領域摘要:

本人之研究領域乃針對光學與超音波在生物醫學上之應用,以深入瞭解物理機制為核心,信號處理演算法則為工具,提昇臨床及研究價值為目標,發展創新醫療技術為手段。目前之主要研究方向包括:

A. 光聲分子影像:光聲效應是利用物體對短脈衝光的吸收及對應的熱膨脹現象,進而產生聲波的特殊效應,利用此光聲效應,可以發揮光學的高對比之吸收光譜特性,結合聲波弱散射與高穿透的優勢,進行影像並探索各種尺度下細胞與組織的結構以及功能。此外,光聲影像亦可結合適當的分子探針,進行分子影像。

B. 光聲藥物輸送:結合光熱特性與聲學的穴蝕效應發展新的藥物輸送技術,特別是利用奈米液滴及微氣泡作為載體,使用雷射與超音波產生液滴汽化與氣泡穴蝕效應,提升聲穿孔效應之綜效,在細胞實驗與動物活體實驗皆可大幅提升藥物輸送的效果。

C. 光聲細胞微環境彈性測量:結合光學偵測與聲輻射力效應來進行三維細胞培養系統之剪切波彈性量測,成為研究生物力學的有效工具。此技術主要是用以探討細胞在三維環境下,細胞微環境之力學特性對於細胞行為與藥物治療的影響。

Research Summary:

My research interests focus on biomedical applications of the combination of light and sound, emphasizing the underlying physics and signal processing algorithms. The ultimate goal is to solve clinical problems with innovative technologies. The current research topics include:

  1. Photoacoustic molecular imaging: The photoacoustic effects are generated by the optical absorption of short-duration light pulses and the concomitant thermal expansion. Based on these effects, anatomical and functional imaging can be performed at multiple scales by exploiting the benefits of high optical contrast and weak acoustic scattering. With proper molecular probes, photoacoustic molecular imaging can also be performed. 

  2. Drug delivery with light and sound: Novel targeted delivery technologies are being developed by leveraging cavitation-based sonoporation with optical and acoustic energies. The synergistic sonoporation effects demonstrated that the delivery efficiency could be significantly enhanced both in vitro and in vivo. The technique has been applied to both photothermal therapy and radiosensitization for radiation cancer therapy.

  3. Shear wave elasticity imaging with light and sound: The acoustic radiation force is combined with optical detection of shear wave propagation to measure the stiffness of 3D cell culture systems, overcoming a critical challenge in this field. In other words, the acoustic radiation force is used to generate shear waves in the sample, and laser speckle contrast imaging is performed to measure the speed of the propagating shear waves noninvasively. We can explore important issues such as cell movement and microenvironment interaction with this.

Photo of Pai-Chi Li