In our laboratory, we use human endothelial cell as model system to investigate the molecular and physiological functions of lysophospholipids, LPA and S1P. Results published by our laboratory and also by others suggested that LPLs might be important regulators of blood vessel formation. In our recent observations, we found that LPLs are potent stimulators for the expression of cell adhesion molecules and chemotatic factors of endothelial cells. Our results suggest that LPL might play important roles in regulating endothelial cell functions.
In addition, we also generated cell lines that are sensitive to dioxin-like compounds. We attempted to use the generated cell lines to setup a biological detection system to sensitively determine the concentrations of these toxic compounds in different sample sources.