魏安祺助理教授的個人資料 - Profile of An-Chi Wei

魏安祺 An-Chi Wei

國立台灣大學電機工程學系 助理教授
Assistant Professor, Department of Electrical Engineering, National Taiwan University

主要研究領域:

系統生物學、生物系統模型建構模擬、生物能量與代謝、線粒體

Major Research Areas:

systems biology, modeling and simulation of biological systems, bioenergetics and metabolism, mitochondria

研究領域摘要:

整合計算模擬與實驗,用系統生物學的角度來了解細胞能量的供應與需求。研究方法以發展線粒體計算模型為基礎,並由直接的實驗測量來驗證,透過緊密的理論與實驗的配合,提供線粒體如何影響正常和病變的能量狀態的全面了解。在未來該模型可提供細胞器官模型及藥物設計的基礎,並可被用於優化治療的設計,以達到最大的保護作用。

主要研究方向為: (1) 線粒體鈣離子的調控,並建立他們對生物能量和細胞生命和凋亡之影響(2)闡明代謝相關疾病中線粒體功能的改變及疾病機制 (3) 整合電腦模擬與定量實驗,研發粒腺體與細胞模型 (4)代謝網路分析

Research Summary:

The objective of my research is to apply recent advances in systemic and quantitative methods to characterize the properties of crucial ion transporters in mitochondria, examine their functional roles in the mitochondrial ion circuits, and develop computational model of mitochondrial ion dynamics and energetics. The goal is to elucidate the roles of mitochondrial ion transport in energy supply and demand matching, integrated cell function, and the progression of disease. The model may ultimately be used to optimize the design of therapeutic agents in order to maximize protective effects.

Photo of An-Chi Wei