劉浩澧教授的著作列表 - Publication List of Hao-Li Liu

Publication List of 劉浩澧 Hao-Li Liu

Journal articles & book chapters:

  1. YJ Ho, CC Huang, CH Fan, HL Liu*, CK Yeh*, “Ultrasonic Technologies in Imaging and Drug Delivery,” Cellular and Molecular Life Sciences, 1-20, Jun. 2021
  2. KT Chen, KC Wei, HL Liu*, “Focused Ultrasound Combined with Microbubbles in Central Nervous System Applications,” Pharmaceutics , 1084, 1-20, May 2021
  3. S Fadera, PY Chen, HL Liu*, IC Lee*, “Induction Therapy of Retinoic acid with a TMZ-loaded Gold Nanoparticle-Associated Ultrasound Effect on Glioblastoma Cancer Stem-like Colonies,” ACS Applied Materials & Interfaces, pp. 1-11 2021 , 1-21, Mar. 2021
  4. KT Chen, WY Chai, YJ Lin, CJ Lin, PY Chen, HC Tsai, CY Huang, J Kuo, HL Liu*, KC Wei*, “Neuronavigation-Guided Focused Ultrasound for Transcranial Blood-Brain-Barrier Opening and Immunostimulation in Brain Tumors,” Science Advances, Vol. 7, 1-13, Jan. 2021
  5. WH Liao, MY Hsiao, Y Kung, HL Liu, JC Béra, C Inserra, WS Chen, “TRPV4 promotes acoustic wave-mediated BBB opening via Ca2+/PKC- pathway,” Journal of Advanced Research, Vol. 26, No.2020,, 15-28, Sept. 2020
  6. Y Kung, HY Huang, WH Liao,AP Huang, MY Hsiao, CH Wu, HL Liu, C Inserra and WS Chen, “A Single High-Intensity Shock Wave Pulse With Microbubbles Opens the Blood-Brain Barrier in Rats,” Frontiers in Bioengineering and Biotechnology, Vol. 8, 42, 1-16, Aug. 2020
  7. YJ Ho, JP Li, CH Fan, HL Liu*, CK Yeh*, “Ultrasound in Tumor Immunotherapy: Current Status and Future Developments,” Journal of Controlled Release, Vol. 323, 12-23, Jul. 2020
  8. K Yang, Q Li, HL Liu, CK Chen, CW Huang, JR Chen, YW Tsai, Z Zhou, PH Tsui, “Frequency-domain CBE imaging for ultrasound localization of the HIFU focal spot: a feasibility study,” Scientific Reports, Vol. 10, No. 1:5468, 1-12, May 2020
  9. CY Lin, CH Tsai, YC Lin, CY Huang, SR Wu, CM Chen, Hao-Li Liu*, “Ultrasound-Responsive Neurotrophic Factor-Loaded Microbubble-Liposome Complex: Preclinical Investigation for Parkinson's Disease Treatment,” Journal of Controlled Release, Vol. 321, 519-528, Mar. 2020
  10. SG Chen, CH Tsai, CJ Lin, CC Lee, HY Yu, TH Hsieh, HL Liu*,, “Transcranial focused ultrasound pulsation suppresses pentylenetetrazol induced epilepsy in vivo,” Brain Stimulation, Vol. 13, 35-46, Jan. 2020
  11. AH Liao, KH Lin, HC Chuang, CH Tsai, YC Lin, CH Wang, CP Shih, and HL Liu*, “Low-frequency dual-frequency ultrasound-mediated microbubble cavitation for transdermal minoxidil delivery and hair growth enhancement,” Scientific Reports, Vol. 10, No. 1:4338, 1-12, Jan. 2020
  12. CH Wu, HL Liu, CT Ho, PH Hsu, CH Fan, CK Yeh, ST Kang, WS Chen, FN Wang, HH Peng, “Monitoring of acoustic cavitation in microbubble-presented focused ultrasound exposure using gradient-echo magnetic resonance imaging,,” Journal of Magnetic Resonance Imaging, Vol. 51, No. 1, 311-318, 2020
  13. KT Chen, KC Wei and HL Liu*, “Theranostic Strategy of Focused Ultrasound Induced Blood-Brain Barrier Opening for CNS Disease Treatment,” Frontiers in Pharmacology, Vol. 10, 1-16, 2019
  14. CY Lin, CH Tsai, LY Feng, WY Chai, CJ Lin, CY Huang, KC Wei, CK Yeh, CM Chen, HL Liu*, “Focused Ultrasound-Induced Blood Brain-Barrier Opening Enhanced Vascular Permeability for GDNF Delivery in Huntington's Disease Mouse Model,” Brain Stimulation, Vol. 12, No. 5, 1143-1150, 2019
  15. CJ Lin, CY Lin, YT Lin, CY Huang, KC Wei, JC Chen, GJL Chen, HL Liu*, “Microbubble-Facilitated Ultrasound Pulsation Promotes Direct α-Synuclein Gene Delivery,” Biochemical and Biophysical Research Communications, Vol. 517, No. 1, 77-83, 2019
  16. IC Lee, ab S Faderaa, HL Liu*, “Strategy of differentiation therapy: effect of dual-frequency ultrasound on the induction of liver cancer stem-like cells on a HA-based multilayer film system,” Journal of Materials Chemistry B, Vol. 7, No. 35, 5401-5411, 2019
  17. A Rotenberg, CH Juan, YC Pei, HL Liu, XJ Feng, YZ Huang, TH Hsieh, YH Chiang and JY Wang,, “Neuromodulatory Effects of Transcranial Direct Current Stimulation on Motor Excitability in Rats,” Neural Plasticity, Vol. 2019: 4252923, 1-11, 2019
  18. C Cornua, M Guédraa, J-C Béraa, HL Liu, WS Chen, C Inserraa, “Ultrafast monitoring and control of subharmonic emissions of an unseeded bubble cloud during pulsed sonication,,” Ultrasonics Sonochemistry, Vol.42, 697-703, 2018
  19. MT Tsai, JW Zhang, KC Wei, CK Yeh, HL Liu*, “Assessment of temporary cerebral effects induced by focused ultrasound with optical coherence tomography angiography,” Biomedical Optics Express, Vol. 9, No. 2, 507-517, 2018
  20. Y Kung, C Lan, MY Hsiao, MK Sun, YH Hsu, APH Liao, WH Liao, HL Liu, C Inserra, WS Chen, “Focused shockwave induced blood-brain barrier opening and transfection,,” Scientific Reports, Vol. 2218, 1-12, 2018
  21. ZH Zhou, SC Wu, MY Lin, J Fang, HL Liu*, and PH Tsui*, “Three-dimensional visualization of ultrasound backscatter statistics by window-modulated compounding Nakagami imaging,” Ultrasonic Imaging, Vol. 40, No. 3 , 171-189, 2018
  22. WY Chai, PC Chu, CH Tsai, CY Lin, HW Yang, HY Lai, HL Liu*, “Image-Guided Focused-Ultrasound CNS Molecular Delivery: An Implementation via Dynamic Contrast-Enhanced Magnetic-Resonance Imaging,” Scientific Reports, Vol. 8:4151, 1-12, 2018
  23. CH Tsai, KT Chen, YX Lin, YC Lin, WS Chen, C Inserra, and HL Liu*,, “Acoustic Emission-Feedback Planar Ultrasound System for Localized Blood-Brain Barrier Opening Monitoring,” Journal of Medical and Biological Engineering, Vol. 39, No. 3, 277-286, 2018
  24. PH Hsu, YT Lin, YH Chung, KJ Lin, LY Yang, TC Yen, and HL Liu*, “Focused Ultrasound-Induced Blood-Brain Barrier Opening Enhances GSK-3 Inhibitor Delivery for Amyloid-Beta Plaque Reduction,” Scientific Reports, Vol. 8, 1-12, 2018
  25. SM Huang, HL Liu, DW Li, and ML Li,, “Ultrasonic Nakagami Imaging of High-intensity Focused Ultrasound-Induced Thermal Lesions in Porcine Livers: Ex Vivo Study,” Ultrasonic Imaging, Vol. 40, No. 5, 310-324, 2018
  26. HL Liu*, CH Tsai, CK Jan, HY Chang, SM Huang, ML Li, W Qiu, H Zheng, “Design and Implementation of a Dual-Transmit/Receive-Mode Therapeutic Ultrasound Phased Array System for Brain Therapy,,” IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, Vol. 65 , No. 10, 1756 -1767, 2018
  27. HC Tsai, CH Tsai, WS Chen, C Inserra, KC Wei, HL Liu*, “Safety evaluation of frequent application of microbubble-enhanced focused ultrasound blood-brain-barrier opening,” Scientific Reports, Vol. 8 , 1-13, 2018
  28. IC Lee, HJ Wu, HL Liu*, “Dual-frequency ultrasound induces neural stem/progenitor cell differentiation and growth factor utilization by enhancing stable cavitation,” ACS Chemical Neuroscience, Vol. 10, 1-18, 2018
  29. HH Peng, CH Wu, ST Kang, JW Zhang, HL Liu, WS Chen, CH Wang, CK Yeh, “Real-Time Monitoring of Inertial Cavitation Effects of Microbubbles by Using MRI: In Vitro Experiments,” Vol. 77, No. 1, Magnetic Resonance in Medicine, 102-111, 2017
  30. P Rwei, CSA Gong, LJ Luo, MB Lin, JY Lai*, HL Liu*, , “In vitro investigation of ultrasound-induced oxidative stress on human lens epithelial cells,,” Biochemical and Biophysical Research Communications, Vol. 482, 954-960, 2017
  31. PY Chen, CK Yeh, PH Hsu, CY Lin, CY Huang, KC Wei, HL Liu*, “Drug-carrying Microbubbles as a Theranostic Tool in Convection-Enhanced Delivery for Brain Tumor Therapy,” Oncotarget, Vol. 8, No. 26, 42359-42371, 2017
  32. SK Wu, PC Chu, WY Chai, ST Kang, CH Tsai, CH Fan, CK Yeh, HL Liu*, , “Characterization of Different Microbubbles in Assisting Focused Ultrasound-Induced Blood-Brain Barrier Opening,” Scientific Reports, No. 7, 46689, 2017
  33. Lee, JC Yeh, CH Tsai, JT Yang, SL Lou, CJ Seak, CY Wang, KC Wei, HL Liu*, “mproved thrombolytic effect with focused ultrasound and neuroprotective agent against acute carotid artery thrombosis in rat,” Scientific Reports, Vol. 7, No. 1, 1638, 2017
  34. CH Fan, CY Lin, HL Liu*, and CK Yeh*, “Ultrasound Targeted CNS Gene Delivery for Parkinson’s Disease Treatment,” Journal of Controlled Release, Vol. 261, 246-262, 2017
  35. FCM Wu, WH Hsu, HL Liu, T Yonezawa,A Balcytis, S Juodkazis,and K Hatanaka, “Photoacoustic signal enhancements from gold nano-colloidal suspensions excited by a pair of polarized time-delayed femtosecond pulses,” Optics Express, Vol. 25, 19497-19507, 2017
  36. J Xia, PH Tsui, HL Liu*, “Low-Pressure Burst-Mode Focused Ultrasound Wave Reconstruction and Mapping for Blood-Brain Barrier Opening: A Preclinical Examination,,” Scientific Reports, No. 6, 27939, 2016
  37. FCP Masim, HL Liu, M Porta, T Yonezawa, A Balcytis, S Juodkazis, WH Hsu, and K Hatanaka, “Enhanced photoacoustics from gold nano-colloidal suspensions under femtosecond laser excitation,” Optics Express, Vol. 24, No. 13, 14781-14792, 2016
  38. FCP Masim, WH Hsu, CH Tsai, HL Liu, M Porta, MT Nguyen, T Yonezawa, A Balcytis, X Wang, S Juodkazis, and K Hatanaka, “MHz-ultrasound generation by chirped femtosecond laser pulses from gold nano-colloidal dispersions,” Optics Express, Vol. 24, No. 15, 24050-24059, 2016
  39. PC Chu, Wen-Yen Chai, CH Tsai, ST Kang, CK Yeh and HL Liu*, “Focused Ultrasound-Induced Blood-Brain Barrier Opening: Association with Mechanical Index and Cavitation Index Analyzed by Dynamic Contrast-Enhanced Magnetic-Resonance Imaging,” Scientific Reports, No. 6, 33264, 2016
  40. MT Tsai, JW Zhang, YH Liu, CK Yeh, KC Wei, and HL Liu*, “Acoustic-actuated optical coherence angiography,” Optics Letters, Vol. 41, 5813-5816, 2016
  41. CH Fan, CY Ting, CY Lin, HL Chan, YC Chang, YY Chen, HL Liu*, and CK Yeh*, “Noninvasive, Targeted, and Non-Viral Ultrasound-Mediated GDNF-Plasmid Delivery for Treatment of Parkinson's Disease,” Scientific Reports, No 6., e19579, 2016
  42. CH Tsai, JW Zhang, YY Liao, HL Liu*, “Real-time monitoring of focused ultrasound blood-brain barrier opening via subharmonic acoustic emission detection: Implementation of confocal dual-frequency piezoelectric transducers,” Physics in Medicine and Biology, Vol. 61, 2926-2946, 2016
  43. HL Liu, PH Hsu, CY Lin, CW Huang, WY Chai, PC Chu, CY Huang, PY Chen, LY Yang, JS Kuo, KC Wei*, “Focused Ultrasound Enhances CNS Delivery of Bevacizumab for Malignant Glioma Treatment,” Radiology, Vol. 281, 99-108, 2016
  44. MT Tsai, IC Lee, ZF Lee, HL Liu, YC Choia, CC Wang, JD Lee1*, “In vivo evaluation of temporal effects and drug delivery induced by transdermal microneedles with optical coherence imaging,” Biomedical Optics Express, Vol. 7, No. 5,, 1865-1876, 2016
  45. CH Fan, YH Cheng, CY Ting, YJ Ho, PH Hsu, HL Liu*, CK Yeh*, “Ultrasound/Magnetic Targeting with SPIO-DOX-Microbubble Complex for Image-Guided Drug Delivery in Brain Tumors,” Theranostics, Vol. 6, No. 10, 1542-1556, 2016
  46. SS Li, CW Lin, KC Wei, CY Huang, PH Hsu, HL Liu, YJ Lu, SC Lin, HW Yang*, CCM Ma*, “Non-invasive screening for early Alzheimer's disease diagnosis by a sensitively immunomagnetic biosensor,” Scientific Reports, No. 6, 25155, 2016
  47. CY Lin, HY Hsieh, CM Chen, SR Wu, CH Tsai, CY Huang, MY Hua, KC Wei, CK Yeh, and HL Liu*,, “Non-invasive, Neuron-Specific Gene Therapy by Focused Ultrasound-Induced Blood-Brain Barrier Opening in Parkinson’s Disease Mouse Model,” Journal of Controlled Release, Vol. 235, 72-81, 2016
  48. YW Chen, TY Liu, PH Chang, PH Hsu, HL Liu, HC Lin, SY Chen, “A theranostic nrGO@MSN-ION nanocarrier developed to enhance the combination effect of sonodynamic therapy and ultrasound hyperthermia for treating tumor,” Nanoscale, Vol. 8, No. 25, 12648-12657, 2016
  49. HY Huang**, HL Liu**, PH Hsu, CS Chiang, CH Tsai, HS Chi, SY Chen, and YY Chen*, “Multitheragnostic Nanobubble System to Induce Brain-Blood Barrier Disruption with Magnetically Guided Focused Ultrasound,” Advanced Materials, Vol. 27, 655-661, 2015
  50. CH Fan, CY Ting, YC Chang, KC Wei, HL Liu*, and CK Yeh*, “Drug-loaded Bubbles with Matched Focused Ultrasound Excitation for Concurrent Blood-Brain Barrier Opening and Brain-Tumor Drug Delivery,” Acta Biomaterialia, Vol. 15, 89-101, 2015
  51. PY Chen, HY Hsieh, CY Huang, CY Lin, KC Wei, and HL Liu*, “Focused Ultrasound-Induced Blood-Brain Barrier Opening to Enhance Interleukin-12 Delivery for Brain Tumor Immunotherapy: A Preclinical Feasibility Study,” Journal of Translational Medicine, Vol. 13, No. 93, 1-12, 2015
  52. CY Lin, HY Hsieh, WG Pitt, CY Huang, IC Tseng, CK Yeh, KC Wei, HL Liu*, “Focused Ultrasound-Induced Blood-Brain Barrier Opening for Non-Viral, Non-invasive, and Targeted Gene Delivery,” Journal of Controlled Release, Vol. 21, 1-9, 2015
  53. PC Chu**, HL Liu**, HY Lai, CY Lin, HC Tsai, YC Pei,, “Neuromodulation accompanying focused ultrasound-induced blood-brain barrier opening,” Scientific Reports, Vol. 5, 15477, 2015
  54. HW Yang, CY Huang, CW Lin, HL Liu, CW Huang, SS Liao, PY Chen, PW Hsu, YJ Lu, KC Wei, CCM Ma, “Gadolinium-functionalized nanographene oxide as a nanocarrier for combined drug and microRNA delivery and magnetic resonance imaging,” Biomaterials, Vol., 35, No. -42, 6534-6542, 2014
  55. HL Liu, CH Fan, CY Ting, and CK Yeh, “Combining Microbubbles and Ultrasound for Drug Delivery to Brain Tumors,” Theranostics, Vol. 4, No. 4, 432-444, 2014
  56. HL Liu*, CK Jan, PC Chu, JC Hong, PY Lee, JD Hsu, CC Lin, CY Huang, PY Chen, and KC Wei*, “Design and Experimental Evaluation of a 256-Channel Dual-Frequency Ultrasound Phased-Array System for Transcranial Blood-Brain Barrier Opening and Brain Drug Delivery,” IEEE Transactions on Biomedical Engineering, Vol. 61, No. 4, 1350-1360, 2014
  57. X Geng, Z Zhou, Q Li, S Wu, CY Wang, HL Liu, CC Chuang, and PH Tsui, “Comparison of ultrasound temperature imaging with infrared thermometry during radio frequency ablation,” Japanese Journal of Applied Physics,” Vol. 53, No. 4, 047001, 2014
  58. CH Fan**, HL Liu**, CY Ting, YH Lee, CY Huang, YJ Ma, KC Wei, TC Yen and CK Yeh, “Submicron-Bubble-Enhanced Focused Ultrasound for Blood–Brain Barrier Disruption and Improved CNS Drug Delivery,” PLoS ONE, Vol.9, No. 5, e96327, 2014
  59. J Xia, Q Li,PY Chen, Z Zhou,CY Wang, HL Liu, J Teng, and PH Tsui, “Considering Angle Selection When Using Ultrasound Electrode Displacement Elastography to Evaluate Radiofrequency Ablation of Tissues,” BioMed Research International,, Vol 2014, 764320, 2014
  60. WY Chai, PC Chu, MY Tsai, YC Lin, JJ Wang, KC Wei, YY Wai and HL Liu*, “Magnetic-Resonance Imaging for Kinetic Analysis of Permeability Changes during Focused Ultrasound-Induced Blood-Brain Barrier Opening and Brain Drug Delivery,” Journal of Controlled Release, Vol. 192, 1-9, 2014
  61. CH Fan, WH Lin, CY Ting, WY Chai, TC Yen, HL Liu* and CK Yeh*, “Contrast-Enhanced Ultrasound Imaging for the Detection of Focused Ultrasound-Induced Blood-Brain Barrier Opening,” Theranostics, Vol. 4, No. 10, 1014-1025, 2014
  62. MT Tsai, FY Chang, CK Lee, CS Gong, YX Lin, JD Lee, CH Yang, HL Liu*, “Investigation of temporal vascular effects induced by focused ultrasound treatment with speckle-variance optical coherence tomography,” Biomedical Optics Express, Vol. 5, No. 7, 2009-2022, 2014
  63. KJ Chen, EY Chaung, SP Wey, KJ Lin, F Cheng, CC Lin, HL Liu, HW Tseng, CP L, MC W, CM Liu, and HW Sung, “Hyperthermia-Mediated Local Drug Delivery by a Bubble-Generating Liposomal System for Tumor-Specific Chemotherapy,,” ACS Nano, Vol. 8, No. 5, 5105-5115, 2014
  64. HL Liu*, CY Huang, JY Chen, HYJ Wang, PY Chen, and KC Wei, “Pharmacodynamic and Therapeutic Investigation of Focused Ultrasound-induced Blood-Brain Barrier Opening for Enhanced Temozolomide Delivery in Glioma Treatment,” PLoS ONE, Vol. 9, No. 12, e114311, 2014
  65. AH Liao, HY Chou, YL Hsieh, SC Hsu, KC Wei, and HL Liu*, “Enhanced Therapeutic Epidermal growth factor receptor (EGFR) Antibody Delivery via Pulsed Ultrasound with Targeting Microbubbles for Glioma Treatment,” Journal of Medical and Biological Engineering, Vol. 1, pp. 1-9, 1-11, 2014
  66. PY Chen, KC Wei, HL Liu*, “Neural Immune Modulation and Immunotherapy Assisted by Focused Ultrasound Induced Blood-Brain Barrier Opening,” Human Vaccines & Immunotherapeutics, Vol. 11, no. 10, 1-11, 2014
  67. K-C Wei, H-C Tsai, Y-J Lu, H-W Yang, M-Y Hua, M-F Wu, P-Y Chen, C-Y Huang, T-C Yen, and H-L Liu*, “Neuronavigation-Guided Focused Ultrasound-Induced Blood-Brain Barrier Opening: A Preliminary Study in Swine,” American Journal of Neuroradiology, Vol. 34, No. 1, 115-120, 2013
  68. C-H Fan, C-Y Ting, H-L Liu*, C-Y Huang, H-Y Hsieh, T-C Yen, K-C Wei, C-K Yeh, “Antiangiogenic-targeting drug-loaded microbubbles combined with focused ultrasound for glioma treatmen,” Biomaterials, Vol. 34, 2142-2155, 2013
  69. K.J. Chen, H.F. Liang, H.L. Chen, Y.C. Wang, P.Y. Cheng, H.L. Liu, Y.N. Xia, H.W. Sung, “A Thermoresponsive Bubble-Generating Liposomal System for Triggering Localized Extracellular Drug Delivery,” ACS Nano, Vol. 7, No. 1, 438-446, 2013
  70. P-H Hsu, K-C Wei, C-Y Huang, C-J Wen, T-C Yen, C-L Liu, Y-T Lin, J-C Chen, C-R Shen, and H-L Liu*, “Noninvasive and targeted gene delivery into the brain using microbubble-facilitated focused ultrasound,” PLoS ONE, Vol. 8, No. 2, e57682, 2013
  71. C-H Fan, C-Y Ting, H-J Lin, C-H Wang, H-L Liu*, T-C Yen, C-K Yeh*, “SPIO-Conjugated, Doxorubicin-Loaded Microbubbles for Concurrent MRI and Focused-Ultrasound Enhanced Brain-Tumor Drug Delivery,” Biomaterials, Vol. 34, 3706-3715, 2013
  72. KC Wei, PC Chu, HYJ Wang, CY Huang, PY Chen, HC Tsai, YJ Lu, IC Tseng, PY Lee, TC Yen, and HL Liu*,, “Focused Ultrasound-induced Blood–Brain Barrier Opening to Enhance Temozolomide Delivery for Glioblastoma Treatment: A Preclinical Study,,” PLoS ONE, Vol. 8, No. 3, e58995, 2013
  73. PC Chu, WY Chai, HY Hsieh, JJ Wang, SP Wey, CY Huang, KC Wei and HL Liu*, “Pharmacodynamic Analysis of Magnetic Resonance Imaging-Monitored Focused Ultrasound-Induced Blood-Brain Barrier Opening for Drug Delivery to Brain Tumors,” BioMed Research International, Vol. 2013, 627496, 2013
  74. HW Yang, HL Liu**, ML Li, IW Hsi, CT Fan, CY Huang, YJ Lu, MY Hua, HY Chou, JW Liaw, CCM Ma and KC Wei, “Magnetic gold-nanorod/ PNIPAAmMA nanoparticles for dual magnetic resonance and photoacoustic imaging and targeted photothermal therapy,” Biomaterials,, Vol. 34, 5651-5660, 2013
  75. H.W. Yang, M.Y. Hua, T.L. Hwang, K.J. Lin, C.Y. Huang, R.Y. Tsai, C.C.M. Ma, P.H. Hsu, S.P. Wey, P.W. Hsu, P.Y. Chen, Y.C. Huang, Y.J. Lu, T.C. Yen, L.Y. Feng, C.W. Lin, H.L. Liu*, K.C. Wei*, “Noninvasive synergistic treatment of brain tumor by targeted chemotherapeutic delivery and amplified focused ultrasound-hyperthermia using magnetic nanographene oxide,” Advanced Materials, Vol. 25, No. 26, 3605-3611, 2013
  76. CY Wang, TS Yeh, XN Geng, HL Liu, and PH Tsui, “Monitoring Radiofrequency Ablation with Ultrasound Nakagami Imaging,” Medical Physics, Vol.40, No.7, 072901, 2013
  77. MT Tsai, CK Lee, KM Lin, YX Lin, TH Lin, TC Chang and HL Liu*, “Quantitative Observation Evaluation of Focused Ultrasound Induced Vascular Leakage and Deformation after Focused Ultrasound Treatment Exposure via by using Fluorescein Angiography and Optical Coherence Tomography,” Journal of Biomedical Optics, Vol.18, No. 10, 101307, 2013
  78. HW Yang, YJ Lu, KJ Lin, SC Hsu, CY Huang, SH She, HL Liu, MC Xiao, SP Wey, PY Chen, TC Yen, KC Wei, CCM Ma, “EGRF conjugated PEGylated nanographene oxide for targeted chemotherapy and photothermal therapy,” Biomaterials, Vol. 34, No. 29, 7204-7214, 2013
  79. YW Huang, SH Hu, SY Hung, CS Chiang, HL Liu, TL Chiou, HY Lai, YY Chen,, “SPIO Nanoparticle-Stabilized Nanobubbles with MR/US Dual-Modality Imaging and HIFU-triggered Release Drug for in-vivo Therapy,” Journal of Controlled Release, Vol. 172 , 118-127, 2013
  80. JJ Xia, Q Li, HL Liu, WS Chen and PH Tsui, “An Approach for the Visualization of Temperature Distribution in Tissues According to Changes in Ultrasonic Backscattered Energy,” Computational and Mathematical Methods in Medicine, Vol 2013, 682827, 2013
  81. C-Y Ting, C-H Fan, H-L Liu*, C-Y Huang, H-Y Hsieh, T-C Yen, K-C Wei, C-K Yeh*,, “Concurrent blood-brain barrier opening and local drug delivery using drug-carrying microbubbles and focused ultrasound for brain glioma treatment,” Biomaterials, Vol. 33, 704-712, 2012
  82. H-L Liu, H-W Yang, M-Y Hua, and K-C Wei, “Enhanced Therapeutic Agent Delivery via MRI-Monitored Focused Ultrasound Blood-Brain Barrier Disruption for Brain Tumor Treatment: An Overview of the current Preclinical Status,” Neurosurgical Focus, Vol. 32, No. 1, 1-11, 2012
  83. Y-C Lin, T-H Chan, C-Y Chi, S-H Ng, H-L Liu, K-C Wei, Y-Y Wei, C-C Wang, J-J Wang, “Blind Estimation of Arterial Input Function in Dynamic Contrast-Enhanced MRI using Purity Maximization,” Magnetic Resonance in Medicine, Vol. 68, No. 5, 1439-1449, 2012
  84. H-W Yang**, M-Y Hua**, H-L Liu**, R-Y Tsai, C-K Chuang, P-C Chu,P-Y Wu, Y-H Chang, H-C Chuang, K-J Yu, and S-T Pang, “Cooperative dual-activity targeted nanomedicine for specific and effective prostate cancer therapy,” ACS Nano, Vol.6, No. 2, 1795-1805, 2012
  85. H-W Yang**, M-Y Hua**, H-L Liu**, R-Y Tsai, S-T Pang, P-H Hsu, H-J Tang, T-C Yen, C-K Chuang, “An epirubicin-conjugated nanocarrier with MRI function to overcome lethal multidrug-resistant bladder cancer,” Biomaterials, Vol. 33, 3919-3930, 2012
  86. P-H Tsui, Y-T Chien, H-L Liu, Y-C Shu, W-S Chen,, “Using ultrasound CBE imaging without echo shift compensation for temperature estimation,” Ultrasonics, Vol. 52, No. 7, 925-935, 2012
  87. C-H Fan, H-L Liu, C-Y Huang, Y-J Ma, T-C Yen, C-K Yeh, “Detection of intracerebral hemorrhage and transient blood-supply shortage in focused ultrasound-induced blood-brain-barrier disruption by ultrasound imaging,” Ultrasound in Medicine and Biology, Vol. 38, No. 8, 1372-1382, 2012
  88. P-H Wang**, H-L Liu**, P-H Hsu, C-R C Wang, P-Y Chen, K-C Wei, T-C Yen, and M-L Li, “Gold-nanorod contrast-enhanced photoacoustic micro-imaging of focused- ultrasound induced blood-brain barrier opening in a rat model,” Journal of Biomedical Optics, Vol. 17, No. 6, 1-7, 2012
  89. P-H Tsui, Y-C Shu, W-S Chen, H-L Liu, I-T Hsiao, and Y-T Chien, “Ultrasound temperature estimation based on probability variation of backscatter data,” Medical Physics, Vol. 39, No. 5, 2369-2385, 2012
  90. A-H Liao, H-L Liu**, C-H Su, M-Y Hua, H-W Yang, Y-T Weng, P-H Hsu, S-M Huang, S-Y Wu, H-El Wang, T-C Yen and P-C Li, “Paramagnetic Perfluorocarbon-Filled Albumin-(Gd-DTPA) Microbubbles for the Induction of Focused-Ultrasound-Induced Blood–Brain Barrier Opening and Concurrent MR and Ultrasound Imaging,” Physics in Medicine and Biology, Vol. 57, 2787-2802, 2012
  91. C-J Ke, Y-J Lin, Y-C Hua, W-L Chiang, K-J Chen, W-C Yang, H-L Liu, C-C Fu, H-W Sung, “Multidrug release based on microneedle arrays filled with pH-responsive PLGA hollow microspheres,” Biomaterials, Vol. 33, No. 20, 5156-5165, 2012
  92. Y-H Ma, S-Y Chen, S-J Tu, H-W Yang, H-L Liu, “Manipulation of magnetic nanoparticle retention and hemodynamic consequences in microcirculation: assessment by laser speckle imaging,” International Journal of Nanomedicine, Vol. 7, 1-11, 2012
  93. P-H Liao, H-H Yang, P-T Chou, M-H Wang, P-C Ju, H-L Liu, and L-K Chen, “Sufficient virus-neutralizing antibody in the central nerve system improves the survival of rabid rats,” Journal of Biomedical Sciences, Vol. 19, 1-12, 2012
  94. A-H Liao, Y-K Li, W-J Lee, M-F Wu, H-L Liu, and M-L Kuo, “Estimating the Delivery Efficiency of Drug-Loaded Microbubbles in Cancer Cells with Ultrasound and Bioluminescence Imaging,” Ultrasound in Medicine and Biology, Vol. 38, No. 11, 1938-1948, 2012
  95. H-W Yang, M-Y Hua, H-L Liu, C-Y Huang, K-C Wei, “Potential of magnetic nanoparticles for targeted drug delivery,” Nanotechnology, Science and Applications, Vol. 5 , 73-86, 2012
  96. H-W Yang, M-Y Hua, K-J Lin, S-P Wey, R-Y Tsai, S-Y Wu, Y-C Lu, H-L Liu, Tony Wu, Y-H Ma, “Bioconjugation of recombinant tissue plasminogen activator to magnetic nanocarriers for targeted thrombolysis,” International Journal of Nanomedicine, Vol. 7, 1-11, 2012
  97. H-W Yang, M-Y Hua, K-J Lin, S-P Wey, R-Y Tsai, S-Y Wu, Y-C Lu, H-L Liu, Tony Wu, Y-H Ma, “Bioconjugation of recombinant tissue plasminogen activator to magnetic nanocarriers for targeted thrombolysis,” International Journal of Nanomedicine, Vol. 7, 1-11, 2012
  98. H-L Liu, H-Y Hsieh, L-A Lu, C-W Kang, M-F Wu and C-Y Lin, “Low-Pressure Pulsed Focused Ultrasound with Microbubbles Promotes an Anticancer Immunological Response,” Journal of Translational Medicine, Vol. 10: 221 , 1-12, 2012
  99. M-Y Hua**, H-L Liu**, H-W Yang, P-Y Chen, R-Y Tsai, C-Y Huang, I-C Tseng, L-A Lyu, C-C Ma, H-J Tang, T-C Yen, K-C Wei, “The effectiveness of a magnetic-nanoparticle-based delivery system for BCNU in the treatment of gliomas,” Biomaterials, Vol. 32 , 512-523, 2011
  100. H-L Liu, M-L Li, P-H Tsui, M-S Lin, S-M Huang, and J Bai,, “An Unified Approach to Combine Temperature Estimation and Elastography for Thermal Lesion Determination in Focused Ultrasound Thermal Therapy,” Physics in Medicine and Biology, Vol. 56, 169-186, 2011
  101. W-S Chen, C-C Shen, C-T Ko, C-H Cheng, H-L Liu, M-C Ho, C-N Chen, C-K Yeh, “Single-Element Ultrasound Transducer for Combined Vessel Localization and Ablation,” IEEE Trans. Ultrason. Ferroelectrics Freq. Contr., Vol. 58, No. 4, 766-775, 2011
  102. H-W Yang**, M-Y Hua**, H-L Liu**, C-Y Huang, R-Y Tsai, Y-J Lu, J-Y Chen, H-J Tang, H-Y Hsien, Y-S Chang, T-C Yen, P-Y Chen and K-C We, “Self-protecting core-shell magnetic nanoparticles for targeted, traceable, long half-life delivery of BCNU to gliomas,” Biomaterials, Vol. 32, 6523-6532, 2011
  103. H-L Liu, P-Y Chen, H-W Yang, J-S Wu, I-C Tseng, Y-J Ma, C-Y Huang, H-C Tsai, S-M Chen, Y-J Lu, C-Y Huang, M-Y Hua, Y-H Ma, T-C Yen and K-C Wei,, “n Vivo MR Quantification of Superparamagnetic Iron Oxide Nanoparticle Leakage During Low-frequency-ultrasound–induced Blood–Brain Barrier Opening In Swine,” Journal of Magnetic Resonance Imaging, Vol. 34, No. 12, 1313-1324, 2011
  104. J-J Wang , W-Y Lin, C-S Lu, Y-H Weng, S-H Ng, C-H Wang , H-L Liu, R-H Hsieh , Y-L Wan, and Y-Y Wai,, “Parkinson Disease_Diagnostic Utility of Diffusion Kurtosis Imaging,” Radiology, Vol. 261, No. 1, 210-217 , 2011
  105. M-Y Hua**, H-W Yang**, H-L Liu**, R-Y Tsai, S-T Pang, K-L Chuang, Y-S Chang, T-L Hwang, Y-H Chang, H-C Chuang, C-K Chuang, “Superhigh-magnetization nanocarrier as a doxorubicin delivery platform for magnetic targeting therapy,” Biomaterials, Vol. 32, 8999-9910, 2011
  106. C-J Ke, T-Y Su, H-Chen, H-L Liu, W-L Chiang, P-C Chu, Y Xia, H-W Sung, “Smart Multifunctional Hollow Microspheres for the Quick Release of Drugs in Intracellular Lysosomal Compartments,” Angewandte Chemie International Edition, Vol. 50, No. 35, 8086 -8089, 2011
  107. W-S Chen, H-L Liu, Y.S. Tung, J.C. Wang, Y.H. Ding, C.K. Jan, “Reducing lesion aberration by dual-frequency focused ultrasound ablations,” International Journal of Hyperthermia, Vol. 27, No. 7, 637-647, 2011
  108. M-T Tsai, T-D Chi, H-L Liu, F-Y Chang, C-H Yang, C-K Lee, and C-C Yang, “Microvascular imaging using swept-source optical coherence tomography with single-channel acquisition,” Appl. Phys. Express, Vol. 4, 097001-097003, 2011
  109. H-L Liu, Y-Y Wai, P-H Hsu, L-A Lyu, J-S Wu, C-R Shen, J-C Chen, T-C Yen, and J-J Wang, “In Vivo Assessment of Macrophage CNS Infiltration during Disruption of the Blood–brain Barrier with Focused Ultrasound: A Magnetic Resonance Imaging Study,” Journal of Cerebral Blood Flow & Metabolism, Vol. 30, 168-177, 2010
  110. Y-C Lin, C-C Wang, Y-Y Wai, Y-L Wan,S-H Ng, Y-L Chen, H-L Liu, J-J Wang, “Significant temporal evolution of diffusion anisotropy for evaluating of early response to radiosurgery in patients with vestibular schwannoma: findings from functional diffusion maps,” American Journal of Neuroradiology, Vol. 31, 269-274, 2010
  111. H-L Liu, C-H Pan, C-Y Ting and M-J Hsiao, “Opening of the Blood-Brain Barrier By Low-Frequency (28-kHz) Ultrasound: A Novel Pinhole-Assisted Mechanical Scanning Device,” Ultrasound in Medicine and Biology, Vol. 36, No. 2, 325-335, 2010
  112. H-L Liu, C-L Hsu, S-M Huang and Y-W Hsi, “Focal Beam Distortion and Treatment Planning for Transrib Focused Ultrasound Thermal Therapy: A Feasibility Study Using a Two-dimensional Ultrasound Phased Array,” Medical Physics, Vol. 37, No. 2, 848-860, 2010
  113. H-L Liu, M-Y Hua, P-Y Chen, P-C Chu, C-H Pan, H-W Yang, C-Y Huang, J-J Wang, T-C Yen and K-C Wei,, “Blood–Brain Barrier Disruption by Focused Ultrasound Enhances Delivery of Chemotherapeutic Drugs for Glioblastoma Treatment,” Radiology, Vol. 255, No. 2, 415-425, 2010
  114. P-Y Chen**, H-L Liu**, M-Y Hua, H-W Yang, C-Y Huang, P-C Chu, L-A Lyu, H-C Tsai, S-M Chen, Y-J Lu, J-J Wang, T-C Yen, Y-H Ma, T. Wu, J-P Chen, J-I Chuang, J-W Shin, C. Hsueh, and K-C Wei, “Novel Magnetic/Ultrasound Focusing System Enhances Nanoparticle Drug Delivery for Glioma Treatment,” Neuro-oncology, Vol. 12, No. 10, 1050-1060, 2010
  115. K-C Ju and H-L Liu, “Zero-crossing-tracking technique for noninvasively ultrasonic temperature estimation,” Journal of Ultrasound in Medicine, Vol. 29, 1607-1615, 2010
  116. H-L Liu, M-Y Hua, H-W Yang, C-Y Huang, P-C Chu, J-S Wua, I-C Tseng, J-J Wang, T-C Yen, P-Y Chen, and K-C Wei, “Magnetic resonance monitoring of focused ultrasound/magnetic nanoparticle targeting delivery of therapeutic agents to the brain,” Proceedings of National Academy of Science USA, , Vol. 107, No. 34, 15205-15210, 2010
  117. H-L Liu, S-M Huang, and M-L Li, “High frame rate ultrasound monitoring of high intensity focused ultrasound induced temperature changes: a novel asynchronous approach,” Medical Physics, Vol. 37, No. 11, 5921-5928, 2010
  118. H-L Liu, P-H Hsu, P-J Ju, Y-Y Wai, J-C Chen, C-R Shen, T-C Yen, and J-J Wang, “Magnetic Resonance Imaging Enhanced by Superparamagnetic Iron Oxide Particles: Usefulness for Distinguishing Between Focused Ultrasound-Induced Blood-Brain Barrier Disruption and Brain Hemorrhage,” Journal of Magnetic Resonance Imaging, Vol. 29, No. 1 , 31-38, 2009
  119. H-L Liu and C-M Hsieh, “Single-Transducer Dual-Frequency Ultrasound Generation to Enhance Acoustic Cavitation,” Ultrasononics Sonochemistry, Vol. 16, No. 3, 431-438, 2009
  120. K-J Lin**, H-L Liu**, P-H Hsu, Y-H Chung,W-C Huang, J-C Chen, S-P Wey, T-C Yen, I-T Hsiao, “Quantitative microSPECT/CT for detecting focused ultrasound induced blood-brain barrier opening in the rat,” Nuclear Medicine and Biology, Vol. 36, No. 7, 853-867, 2009
  121. H-L Liu, M-L Li, T-C Shih, S-M Huang, I-Y Lu, D-Y Lin, S-M Lin and K-C Ju, “Instantaneous Frequency Based Ultrasonic Temperature Estimation during Focused Ultrasound Thermal Therapy,” Ultrasound in Medicine and Biology, Vol. 35, No. 10, 1647-1661, 2009
  122. J-J Wang, Y-Y Wai, Y-H Weng, K-K Ng, Y-Z Huang; L. Ying, H-L Liu, and C-H Wang, “Functional MRI in the assessment of cortical activation during gait-related imaginary tasks,,” Journal of Neural Transmission, Vol. 116, 1087 -1092, 2009
  123. H-L Liu, Y-Y Wai, W-S Chen, J-C Chen, P-H Hsu, X-Y W, W-C Huang, T-C Yen, and J-J Wang, “Hemorrhage Detection during Focused-Ultrasound Induced Blood–Brain-Barrier Opening by Using Susceptibility-Weighted Magnetic Resonance Imaging,” Ultrasound in Medicine & Biology, Vol. 34, No. 4, 598-606, 2008
  124. J-J Wang, Y-C Lin, Y-Y Wai, H-L Liu, C-P Lin, Y-Z Huang, “Visualization of the coherence of the principal diffusion orientation: an eigenvector-based approach,” Magnetic Resonance in Medicine, Vol. 59, No. 4, 764-770, 2008
  125. H-L Liu, H-W Chen, Z-H Kuo, and W-C Huang, “Design and Experimental Evaluations of a Low-Frequency Hemispherical Ultrasound Phased-Array System for Transcranial Blood-Brain Barrier Disruption,” IEEE Transactions on Biomedical Engineering, Vol.55, No. 10, 2407-2416, 2008
  126. H-L Liu, W-L Lin, and Y-Y Chen , “A Fast and Conformal Heating Scheme for Producing Large Thermal Lesions Using a 2-D Ultrasound Phased Array,” International Journal of Hyperthermia, Vol. 23, No. 1, 69-82, 2007
  127. H-L Liu , T-C Shih , W-S Chen and K-C Ju, “A Novel Strategy to Increase Heating Efficiency in a Split-Focus Ultrasound Phased Array,” Medical Physics, Vol. 34, No. 7, 2957-2967, 2007
  128. H-L Liu, H Chang, W-S Chen, T-C Shih, J-K Hsiao, and W-L Lin, “Feasibility of Transrib Focused Ultrasound Thermal Ablation for Liver Tumors Using a Spherically Curved 2D Array: A Numerical Study,” Medical Physics, , Vol. 34, No. 9, 3436-3448, 2007
  129. H-L Liu, W-S Chen, J-S Chen, T-C Shih, Y-Y Chen, and W-L Lin, “Cavitation - Enhanced Ultrasound Thermal Therapy by Combined Low- and High-Frequency Ultrasound Exposure,” Ultrasound in Medicine & Biology, Vol. 32, No. 5 , 759-767, 2006
  130. W-S Chen, C-C Wu, S-Y Fang, H-L Liu* , “Differences in the lesion formation process between focused ultrasound and microwave ablations,” Medical Physics , Vol. 33, No. 5, 1346-1351, 2006
  131. H-L Liu, Y-Y Chen, W-S Chen, T-C Shih, J-S Chen, and W-L Lin, “Interactions between consecutive sonications for characterizing the thermal mechanism in focused ultrasound therapy,” Ultrasound in Medicine & Biology, Vol. 32, No. 9, 1411-1421, 2006
  132. H-L Liu, N McDannold, and K Hynynen, “Focal beam distortion and treatment planning in abdominal focused ultrasound surgery,” Medical Physics , 32, 1270-1280, Jan. 2005